An efficient preparation of indolizines through a tandem palladium-catalyzed cross-coupling reaction and cycloisomerization.
نویسندگان
چکیده
An efficient synthetic method for producing indolizines through a tandem Pd-catalyzed selective allenyl cross-coupling reaction using organoindium reagents and cycloisomerization was developed in a one-pot process.
منابع مشابه
Palladium-catalyzed highly efficient synthesis of functionalized indolizines via cross-coupling/cycloisomerization cascade.
An efficient Pd-catalyzed cross-coupling/cycloisomerization of 3-(2-pyridyl) propargyl carbonates with organoboronic acids has been developed, which provides a straightforward route for the synthesis of 1,3-disubstituted indolizines with a wide variety of substituents. The mechanistic study indicates that the reaction proceeds via formation of an allenyl pyridine intermediate through palladium-...
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ورودعنوان ژورنال:
- Chemical communications
دوره 46 34 شماره
صفحات -
تاریخ انتشار 2010